Chris Jacobsen

Professor
PhD, SUNY Stony Brook, 1988

Research group web page

Associate Division Director and Senior Physicst, X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory

Fellow, American Association for the Advancement of Science
Fellow, Optical Society of America
Presidential Faculty Fellow (White House/NSF), 1992
International Dennis Gabor Award (Hungary), 1996
Kurt Heinrich Award (Microbeam Analysis Society), 2001

Chris Jacobsen's research is focused on developing new methods in x-ray microscopy, and applying them to interesting problems in biology, environmental science, and materials science.  Using either diffractive optics (like Fresnel zone plates fabricated using electron beam lithography), or lens-less methods where iterative phase retrieval methods are used to reconstruct an image from a coherent diffraction pattern, images with a spatial resolution of 30 nm or better can be obtained.  In absorption contrast, one can combine imaging with spectroscopy to study chemical speciation at the nanoscale, or one can use fluorescence detection to study trace element distributions with parts-per-billion sensitivity.  We are also developing detectors and image reconstruction algorithms that can be used to obtain quantitative phase contrast images with hard X-rays, and thus put elemental distributions into their ultrastructural context and also go from measurements of content to measurements of concentration (since concentration gradients drive chemical processes).  Finally, we are interested in understanding the limitations that radiation damage presents to x-ray microscopy studies, and in developing both cryo-instrumentation and sample preparation methods to mitigate those limitations.  These efforts require bright x-ray beams, so we use synchrotron radiation sources at Argonne Lab, Berkeley Lab, and elsewhere.  Students in the group explore interesting problems in optical physics and in instrumentation, and get to broaden their perspective by working with collaborators from other research fields like biology, environmental science, and materials science.

Selected Publications

  • C. Holzner, M. Feser, S. Vogt, B. Hornberger, S.B. Baines, and C. Jacobsen, “Zernike phase contrast scanning microscopy with X-rays,” Nature Physics 6, 883-887 (2010)   [PDF logoPDF]
  • M.D. de Jonge, C. Holzner, S.B. Baines, B.S. Twining, K. Ignatyev, J. Diaz, D.L. Howard, D. Legnini, A. Miceli, I. McNulty, C.J. Jacobsen, and S. Vogt, “Quantitative 3D elemental microtomography of Cyclotella meneghiniana at 400-nm resolution,” Proceedings of the National Academy of Sciences 107, 15676-15680 (2010).  [PDF logoPDF]
  • J. Nelson, X. Huang, J. Steinbrener, D. Shapiro, J. Kirz, S. Marchesini, A.M. Neiman, J.J. Turner, and C. Jacobsen, “High resolution x-ray diffraction microscopy of specifically labeled yeast cells,” Proceedings of the National Academy of Sciences 107, 7235 (2010).  [PDF logoPDF]
  • J. Nelson, X. Huang, J. Steinbrener, D. Shapiro, J. Kirz, S. Marchesini, A.M. Neiman, J.J. Turner, and C. Jacobsen, “High resolution x-ray diffraction microscopy of specifically labeled yeast cells,” accepted in Proceedings of the National Academy of Sciences.
  • X. Huang, J. Nelson, J. Kirz, E. Lima, S. Marchesini, H. Miao, A.M. Neiman, D. Shapiro, J. Steinbrener, A. Stewart, J.J. Turner, and C. Jacobsen, “Soft x-ray diffraction microscopy of a frozen hydrated yeast cell,” Physical Review Letters 103, 198101 (2009).  [PDF logo PDF]
  • M. Howells, T. Beetz, H. Chapman, C. Cui, J. Holton, C. Jacobsen, J. Kirz, E. Lima, S. Marchesini, H. Miao, D. Sayre, D. Shapiro, J. Spence, and D. Starodub, “An assessment of the resolution limitation due to radiation-damage in x-ray diffraction microscopy,” Journal of Electron Spectroscopy and Related Phenomena 170, 4–12, 2009.  [PDF logoPDF]
  • M. D. de Jonge, B. Hornberger, D. Paterson, C. Holzner, D. Legnini, I. McNulty, C. Jacobsen, and S. Vogt, “Quantitative phase imaging with a scanning transmission x-ray microscope,” Physical Review Letters 100, 163902 (2008).  [PDF logoPDF]
  • J. Lehmann, D. Solomon, J. Kinyangi, L. Dathe, S. Wirick, and C. Jacobsen, “Spatial complexity of soil organic matter forms at nanometre scales,” Nature Geoscience 1, 238-242 (2008).  [PDF logoPDF]
  • D. Shapiro, P. Thibault, T. Beetz, V. Elser, M. Howells, C. Jacobsen, J. Kirz, E. Lima, H. Miao, A. M. Neiman, and D. Sayre, “Biological imaging by soft x-ray diffraction microscopy,” Proceedings of the National Academy of Sciences 102, 15343-15346 (2005).   [PDF logoPDF]
  • C.K. Boyce, M.A. Zwieniecki, G.D. Cody, C. Jacobsen, S. Wirick, A.H. Knoll, and N. M. Holbrook, “Evolution of xylem lignification and hydrogel transport regulation.”  Proceedings of the National Academy of Sciences 101, 17555-17558 (2004).  [PDF logoPDF]
  • J. Kirz, C. Jacobsen, and M. Howells, “Soft x-ray microscopes and their biological applications.” Quarterly Reviews of Biophysics 28, 33-130 (1995).  [PDF logoPDF]

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August 26, 2013